Back to Search
Start Over
Study of failure pattern among high-risk breast cancer patients with or without postmastectomy radiotherapy in addition to adjuvant systemic therapy: long-term results from the Danish Breast Cancer Cooperative Group DBCG 82 b and c randomized studies.
- Source :
-
Journal of clinical oncology : official journal of the American Society of Clinical Oncology [J Clin Oncol] 2006 May 20; Vol. 24 (15), pp. 2268-75. Date of Electronic Publication: 2006 Apr 17. - Publication Year :
- 2006
-
Abstract
- Purpose: Postmastectomy radiotherapy (RT) in high-risk breast cancer patients can reduce locoregional recurrences (LRRs) and improve disease-free and overall survival. The aim of this analysis was to examine the overall disease recurrence pattern among patients randomly assigned to receive treatment with or without RT.<br />Patients and Methods: A long-term follow-up was performed among the 3,083 patients from the Danish Breast Cancer Cooperative Group 82 b and c trials, except in those already recorded with distant metastases (DM) or contralateral breast cancer (CBC). The end points were LRR, DM, and CBC, and the follow-up continued until DM, CBC, emigration, or death. Information was selected from medical records, general practitioners, and the National Causes of Death Registry. The median potential follow-up time was 18 years.<br />Results: The 18-year probability of any first breast cancer event was 73% and 59% (P < .001) after no RT and RT, respectively (relative risk [RR], 0.68; 95% CI, 0.63 to 0.75). The 18-year probability of LRR (with or without DM) was 49% and 14% (P < .001) after no RT and RT, respectively (RR, 0.23; 95% CI, 0.19 to 0.27). The 18-year probability of DM subsequent to LRR was 35% and 6% (P < .001) after no RT and RT, respectively (RR, 0.15; 95% CI, 0.11 to 0.20), whereas the probability of any DM was 64% and 53% (P < .001) after no RT versus RT, respectively (RR, 0.78; 95% CI, 0.71 to 0.86).<br />Conclusion: Postmastectomy RT changes the disease recurrence pattern in high-risk breast cancer patients; fewer patients have LRR as first site of recurrence, and overall fewer patients have DM.
- Subjects :
- Adult
Antineoplastic Combined Chemotherapy Protocols therapeutic use
Axilla
Breast Neoplasms pathology
Chemotherapy, Adjuvant
Combined Modality Therapy
Cyclophosphamide therapeutic use
Female
Fluorouracil therapeutic use
Follow-Up Studies
Humans
Lymph Node Excision
Mastectomy
Methotrexate therapeutic use
Middle Aged
Neoplasm Metastasis
Neoplasm Recurrence, Local epidemiology
Neoplasm Staging
Risk
Tamoxifen administration & dosage
Treatment Failure
Breast Neoplasms therapy
Neoplasm Recurrence, Local prevention & control
Radiotherapy, Adjuvant
Subjects
Details
- Language :
- English
- ISSN :
- 1527-7755
- Volume :
- 24
- Issue :
- 15
- Database :
- MEDLINE
- Journal :
- Journal of clinical oncology : official journal of the American Society of Clinical Oncology
- Publication Type :
- Academic Journal
- Accession number :
- 16618947
- Full Text :
- https://doi.org/10.1200/JCO.2005.02.8738