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Genomic gain at 6p21: a new cryptic molecular rearrangement in secondary myelodysplastic syndrome and acute myeloid leukemia.
- Source :
-
Leukemia [Leukemia] 2006 Jun; Vol. 20 (6), pp. 958-64. - Publication Year :
- 2006
-
Abstract
- Fluorescence in situ hybridization and comparative genomic hybridization characterized 6p rearrangements in eight primary and in 10 secondary myeloid disorders (including one patient with Fanconi anemia) and found different molecular lesions in each group. In primary disorders, 6p abnormalities, isolated in six patients, were highly heterogeneous with different breakpoints along the 6p arm. Reciprocal translocations were found in seven. In the 10 patients with secondary acute myeloid leukemia/myelodysplastic syndrome (AML/MDS), the short arm of chromosome 6 was involved in unbalanced translocations in 7. The other three patients showed full or partial trisomy of the 6p arm, that is, i(6)(p10) (one patient) and dup(6)(p) (two patients). In 5/7 patients with unbalanced translocations, DNA sequences were overrepresented at band 6p21 as either cryptic duplications (three patients) or cryptic low-copy gains (two patients). In the eight patients with cytogenetic or cryptic 6p gains, we identified a common overrepresented region extending for 5-6 megabases from the TNF gene to the ETV-7 gene. 6p abnormalities were isolated karyotype changes in four patients. Consequently, in secondary AML/MDS, we hypothesize that 6p gains are major pathogenetic events arising from acquired and/or congenital genomic instability.
- Subjects :
- Acute Disease
Adult
Aged
Aged, 80 and over
Cytogenetic Analysis
Female
Humans
In Situ Hybridization, Fluorescence
Leukemia, Myeloid diagnosis
Male
Middle Aged
Myelodysplastic Syndromes diagnosis
Neoplasms, Second Primary diagnosis
Sensitivity and Specificity
Chromosomes, Human, Pair 6 genetics
Leukemia, Myeloid genetics
Myelodysplastic Syndromes genetics
Neoplasms, Second Primary genetics
Translocation, Genetic genetics
Subjects
Details
- Language :
- English
- ISSN :
- 0887-6924
- Volume :
- 20
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Leukemia
- Publication Type :
- Academic Journal
- Accession number :
- 16617324
- Full Text :
- https://doi.org/10.1038/sj.leu.2404208