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Sol-gel molecular imprinted ormosil for solid-phase extraction of methylxanthines.
- Source :
-
Journal of chromatography. A [J Chromatogr A] 2006 May 12; Vol. 1114 (2), pp. 216-23. Date of Electronic Publication: 2006 Apr 17. - Publication Year :
- 2006
-
Abstract
- A organically modified molecularly imprinted silica (MIS), selective for methylxanthines, was prepared using a simple sol-gel procedure. Caffeine was used as template; 3-aminopropyltrimethoxysilane (APTMS) as functional monomer and tetraethyl orthosilicate (TEOS) as reticulating agent. The material was packed on solid-phase extraction (SPE) cartridges and evaluated with aqueous test samples, natural water and human urine; a quantitative method for methylxanthines in water, using SPE cartridges packed with the MIS coupled with HPLC-UV was developed. The MIS was highly specific for methylxanthines, with an imprinting factor of (20.5+/-1.9). The analytical method resulted in detection limits of 85 microgL(-1) for theobromine, 44 microgL(-1) for theophylline and 53 microgL(-1) for caffeine.
Details
- Language :
- English
- ISSN :
- 0021-9673
- Volume :
- 1114
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Journal of chromatography. A
- Publication Type :
- Academic Journal
- Accession number :
- 16616927
- Full Text :
- https://doi.org/10.1016/j.chroma.2006.03.073