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Interaction of adenine nucleotides with the adenine nucleotide translocase regulates the developmental changes in proton conductance of the inner mitochondrial membrane.
- Source :
-
FEBS letters [FEBS Lett] 1991 Dec 09; Vol. 294 (3), pp. 225-8. - Publication Year :
- 1991
-
Abstract
- 2-h-old neonatal liver mitochondria, when depleted of adenine nucleotides, showed an 'ohmic' current-voltage relationship and a higher passive proton permeability of the membrane, resembling fetal mitochondrial behaviors for the proton conductance. Incubation of fetal mitochondria with ATP, GDP or carboxyatractyloside promoted a significant reduction in the passive proton permeability of the membrane and the appearance of the characteristic biphasic behavior for the proton conductance. It is concluded that the postnatal increase in intramitochondrial adenine nucleotide concentration promotes, by the interaction of the nucleotides with the adenine nucleotide translocase, the reduction in the passive proton permeability of the mitochondrial membrane, allowing efficient energy conservation in the neonatal liver.
- Subjects :
- Adenosine Triphosphate pharmacology
Animals
Animals, Newborn
Atractyloside analogs & derivatives
Atractyloside pharmacology
Cell Membrane Permeability drug effects
Electric Conductivity
Guanosine Diphosphate pharmacology
Liver embryology
Rats
Adenine Nucleotides metabolism
Intracellular Membranes physiology
Liver growth & development
Mitochondria, Liver physiology
Mitochondrial ADP, ATP Translocases metabolism
Protons
Subjects
Details
- Language :
- English
- ISSN :
- 0014-5793
- Volume :
- 294
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- FEBS letters
- Publication Type :
- Academic Journal
- Accession number :
- 1661684
- Full Text :
- https://doi.org/10.1016/0014-5793(91)81435-b