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Synthesis and antimicrobial studies of a new series of 2-[4-[2-(5-ethylpyridin-2-yl)ethoxy]phenyl]-5-substituted-1,3,4-oxadiazoles.
Synthesis and antimicrobial studies of a new series of 2-[4-[2-(5-ethylpyridin-2-yl)ethoxy]phenyl]-5-substituted-1,3,4-oxadiazoles.
- Source :
-
European journal of medicinal chemistry [Eur J Med Chem] 2006 Jul; Vol. 41 (7), pp. 841-6. Date of Electronic Publication: 2006 Apr 17. - Publication Year :
- 2006
-
Abstract
- A series of novel 2-[4-[2-(5-ethylpyridin-2-yl)ethoxy]phenyl]-5-substituted-1,3,4-oxadiazoles were synthesized by the oxidative cyclisation of hydrazones derived from 4-[2-(5-ethylpyridin-2-yl)ethoxy]benzaldehyde and aroylhydrazines using chloramine-T as oxidant. IR, NMR and elemental analysis characterized the newly synthesized compounds. The synthesized compounds were evaluated for their antimicrobial activity and were compared with standard drugs. The compounds demonstrated potent to weak antimicrobial activity. Out of the compounds studied, compounds 8c and 8d showed significant inhibition. Compounds 8b, 8f, 8k and 8e showed moderate activity. The minimum inhibitory concentration of the compounds was in the range of 8-26 microg ml(-1) against bacteria and 8-24 microg ml(-1) against fungi. The title compounds represent a novel class of potent antimicrobial agents.
- Subjects :
- Anti-Infective Agents chemistry
Bacillus subtilis drug effects
Gram-Negative Bacteria drug effects
Molecular Structure
Oxadiazoles chemical synthesis
Structure-Activity Relationship
Anti-Infective Agents chemical synthesis
Anti-Infective Agents pharmacology
Oxadiazoles chemistry
Oxadiazoles pharmacology
Pyridines chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 0223-5234
- Volume :
- 41
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- European journal of medicinal chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 16616395
- Full Text :
- https://doi.org/10.1016/j.ejmech.2006.03.002