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LRRK2 in Parkinson's disease: protein domains and functional insights.
- Source :
-
Trends in neurosciences [Trends Neurosci] 2006 May; Vol. 29 (5), pp. 286-93. Date of Electronic Publication: 2006 Apr 17. - Publication Year :
- 2006
-
Abstract
- Parkinson's disease (PD) is the most common motor neurodegenerative disease. Mutations in the gene encoding leucine-rich repeat kinase 2 (LRRK2) have been linked recently with autosomal-dominant parkinsonism that is clinically indistinguishable from typical, idiopathic, late-onset PD. Thus, the protein LRRK2 has emerged as a promising therapeutic target for treatment of PD. LRRK2 is extraordinarily large and complex, with multiple enzymatic and protein-interaction domains, each of which is targeted by pathogenic mutations in familial PD. This review places the PD-associated mutations of LRRK2 in a structural and functional framework, with the ultimate aim of deciphering the molecular basis of LRRK2-associated pathogenesis. This, in turn, should advance our understanding and treatment of familial and idiopathic PD.
- Subjects :
- Humans
Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
Mutation genetics
Parkinson Disease enzymology
Protein Serine-Threonine Kinases chemistry
Protein Structure, Tertiary genetics
Protein Structure, Tertiary physiology
Parkinson Disease genetics
Protein Serine-Threonine Kinases genetics
Protein Serine-Threonine Kinases metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0166-2236
- Volume :
- 29
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Trends in neurosciences
- Publication Type :
- Academic Journal
- Accession number :
- 16616379
- Full Text :
- https://doi.org/10.1016/j.tins.2006.03.006