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Postnatal environment overrides genetic and prenatal factors influencing offspring obesity and insulin resistance.
- Source :
-
American journal of physiology. Regulatory, integrative and comparative physiology [Am J Physiol Regul Integr Comp Physiol] 2006 Sep; Vol. 291 (3), pp. R768-78. Date of Electronic Publication: 2006 Apr 13. - Publication Year :
- 2006
-
Abstract
- There is growing evidence that the postnatal environment can have a major impact on the development of obesity and insulin resistance in offspring. We postulated that cross-fostering obesity-prone offspring to lean, obesity-resistant dams would ameliorate their development of obesity and insulin resistance, while fostering lean offspring to genetically obese dams would lead them to develop obesity and insulin resistance as adults. We found that obesity-prone pups cross-fostered to obesity-resistant dams remained obese but did improve their insulin sensitivity as adults. In contrast, obesity-resistant pups cross-fostered to genetically obese dams showed a diet-induced increase in adiposity, reduced insulin sensitivity, and associated changes in hypothalamic neuropeptide, insulin, and leptin receptors, which might have contributed to their metabolic defects. There was a selective increase in insulin levels and differences in fatty acid composition of obese dam milk which might have contributed to the increased adiposity, insulin resistance, and hypothalamic changes in obesity-resistant cross-fostered offspring. These results demonstrate that postnatal factors can overcome both genetic predisposition and prenatal factors in determining the development of adiposity, insulin sensitivity, and the brain pathways that mediate these functions.
- Subjects :
- Aging
Animal Feed
Animals
Energy Metabolism
Fatty Acids analysis
Female
Gene Expression Regulation
Hormones blood
Hypothalamus metabolism
Male
Milk chemistry
Neuropeptides metabolism
RNA, Messenger metabolism
Rats
Receptors, Neuropeptide metabolism
Weight Gain
Insulin Resistance genetics
Insulin Resistance physiology
Obesity genetics
Obesity metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0363-6119
- Volume :
- 291
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- American journal of physiology. Regulatory, integrative and comparative physiology
- Publication Type :
- Academic Journal
- Accession number :
- 16614055
- Full Text :
- https://doi.org/10.1152/ajpregu.00138.2006