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Hydrophilic molecularly imprinted poly(hydroxyethyl-methacrylate) polymers.

Authors :
Oral E
Peppas NA
Source :
Journal of biomedical materials research. Part A [J Biomed Mater Res A] 2006 Jul; Vol. 78 (1), pp. 205-10.
Publication Year :
2006

Abstract

Highly cross-linked 2-hydroxyethyl methacrylate (HEMA) and poly(ethylene glycol) dimethacrylate with poly(ethylene glycol) of molecular weight 600 (PEG600DMA) were molecularly imprinted with hydrophilic templates glucose and proxyphylline using water as a solvent. Glucose-imprinted polymers showed increased recognitive capacity compared to nonimprinted polymers as well as increased glucose uptake compared to structurally similar galactose and methylglucopyranoside. Increasing glucose concentration in the imprinting mixture resulted in higher capacity and selective binding. Similar results were obtained for proxyphylline-imprinted P(HEMA-co-PEG600DMA) polymers, where the proxyphylline uptake was higher than structurally similar theophylline. Glucose-imprinted networks also showed diffusion coefficients on the order of 10(-6) cm2/s, conducive to applications in drug delivery and tissue engineering. This work showed that using pairs of hydrogen-bonding monomers and templates, selective, high-affinity sites could be created despite nonspecific binding.<br /> (Copyright (c) 2006 Wiley Periodicals, Inc.)

Details

Language :
English
ISSN :
1549-3296
Volume :
78
Issue :
1
Database :
MEDLINE
Journal :
Journal of biomedical materials research. Part A
Publication Type :
Academic Journal
Accession number :
16602126
Full Text :
https://doi.org/10.1002/jbm.a.30725