Back to Search
Start Over
DNA replication during aggregation phase is essential for Myxococcus xanthus development.
- Source :
-
Journal of bacteriology [J Bacteriol] 2006 Apr; Vol. 188 (8), pp. 2774-9. - Publication Year :
- 2006
-
Abstract
- Previous studies have demonstrated that fruiting body-derived Myxococcus xanthus myxospores contain two fully replicated copies of its genome, implying developmental control of chromosome replication and septation. In this study, we employ DNA replication inhibitors to determine if chromosome replication is essential to development and the exact time frame in which chromosome replication occurs within the developmental cycle. Our results show that DNA replication during the aggregation phase is essential for developmental progression, implying the existence of a checkpoint that monitors chromosome integrity at the end of the aggregation phase.
- Subjects :
- Amino Acid Sequence
Chromosomes, Bacterial drug effects
Chromosomes, Bacterial metabolism
DNA Gyrase chemistry
DNA Gyrase genetics
DNA, Bacterial biosynthesis
DNA, Bacterial drug effects
Drug Resistance, Bacterial genetics
Enzyme Inhibitors pharmacology
Molecular Sequence Data
Mutation, Missense
Myxococcus xanthus genetics
Myxococcus xanthus metabolism
Myxococcus xanthus physiology
Nalidixic Acid pharmacology
Photomicrography
Sequence Alignment
Spores, Bacterial physiology
Topoisomerase II Inhibitors
DNA Replication
Myxococcus xanthus growth & development
Subjects
Details
- Language :
- English
- ISSN :
- 0021-9193
- Volume :
- 188
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Journal of bacteriology
- Publication Type :
- Academic Journal
- Accession number :
- 16585738
- Full Text :
- https://doi.org/10.1128/JB.188.8.2774-2779.2006