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Achilles detachment in rat and stable gastric pentadecapeptide BPC 157: Promoted tendon-to-bone healing and opposed corticosteroid aggravation.
- Source :
-
Journal of orthopaedic research : official publication of the Orthopaedic Research Society [J Orthop Res] 2006 May; Vol. 24 (5), pp. 982-9. - Publication Year :
- 2006
-
Abstract
- Stable gastric pentadecapeptide BPC 157 (BPC 157, as an antiulcer agent in clinical trials for inflammatory bowel disease; PLD-116, PL 14736, Pliva, no toxicity reported) alone (without carrier) ameliorates healing of tendon and bone, respectively, as well as other tissues. Thereby, we focus on Achilles tendon-to-bone healing: tendon to bone could not be healed spontaneously, but it was recovered by this peptide. After the rat's Achilles tendon was sharply transected from calcaneal bone, agents [BPC 157 (10 microg, 10 ng, 10 pg), 6alpha-methylprednisolone (1 mg), 0.9% NaCl (5 mL)] were given alone or in combination [/kg body weight (b.w.) intraperitoneally, once time daily, first 30-min after surgery, last 24 h before analysis]. Tested at days 1, 4, 7, 10, 14, and 21 after Achilles detachment, BPC 157 improves healing functionally [Achilles functional index (AFI) values substantially increased], biomechanically (load to failure, stiffness, and Young elasticity modulus significantly increased), macro/microscopically, immunohistochemistry (better organization of collagen fibers, and advanced vascular appearance, more collagen type I). 6alpha-Methylprednisolone consistently aggravates the healing, while BPC 157 substantially reduces 6alpha-methylprednisolone healing aggravation. Thus, direct tendon-to-bone healing using stabile nontoxic peptide BPC 157 without a carrier might successfully exchange the present reconstructive surgical methods.<br /> (Copyright 2006 Orthopaedic Research Society.)
- Subjects :
- Achilles Tendon injuries
Achilles Tendon physiology
Animals
Biomechanical Phenomena
Male
Nitric Oxide physiology
Rats
Rats, Wistar
Tendon Injuries physiopathology
Achilles Tendon drug effects
Adrenal Cortex Hormones toxicity
Anti-Ulcer Agents pharmacology
Peptide Fragments pharmacology
Proteins pharmacology
Tendon Injuries drug therapy
Wound Healing drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 0736-0266
- Volume :
- 24
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Journal of orthopaedic research : official publication of the Orthopaedic Research Society
- Publication Type :
- Academic Journal
- Accession number :
- 16583442
- Full Text :
- https://doi.org/10.1002/jor.20096