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Synthesis of 2-alkoxy-8-hydroxyadenylpeptides: towards synthetic epitope-based vaccines.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2006 Jun 15; Vol. 16 (12), pp. 3258-61. Date of Electronic Publication: 2006 Apr 11. - Publication Year :
- 2006
-
Abstract
- The preparation of three different 2-alkoxy-8-hydroxyadenylpeptide conjugates has been accomplished by solid-phase synthesis combined with 'on-resin' Cu(I) catalyzed Huisgen cycloaddition. The immunogenicity of the compounds has been evaluated in IL-12 production and antigen presentation assays.
- Subjects :
- Adenine chemistry
Antigen Presentation immunology
Dendritic Cells immunology
Histocompatibility Antigens Class I immunology
Interleukin-12 biosynthesis
Molecular Structure
Peptides chemistry
Adenine analogs & derivatives
Epitopes chemistry
Epitopes immunology
Peptides chemical synthesis
Peptides immunology
Vaccines immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0960-894X
- Volume :
- 16
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 16581248
- Full Text :
- https://doi.org/10.1016/j.bmcl.2006.03.034