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New aspects in the pathogenesis of enteropathic hemolytic uremic syndrome.
- Source :
-
Seminars in thrombosis and hemostasis [Semin Thromb Hemost] 2006 Mar; Vol. 32 (2), pp. 105-12. - Publication Year :
- 2006
-
Abstract
- Shiga toxin (Stx) subtyping suggests that the clinical outcome of infections caused by Shiga toxin-producing ESCHERICHIA COLI (STEC) depends, in large part, on the STX genotype of the infecting strain. Whereas the presence of the STX2 or STX2C genotype is associated with the ability of STEC to cause the hemolytic uremic syndrome (HUS), strains possessing STX2D or STX2E have been isolated from patients with less severe disease. In addition to the type of Stx, the level of Stx production might be critical for the pathogenicity of STEC. Control of Stx expression appears to be at the level of transcription. Injury to microvascular endothelial cells is the key event underlying the pathogenesis of HUS. We could show that in addition to Stx, STEC also produces other putative virulence factors, such as cytolethal distending toxin, which can contribute to the endothelial injury by interference with the cell cycle, which results in inhibition of cell proliferation and finally cell death.
- Subjects :
- Bacterial Toxins genetics
Bacterial Toxins toxicity
Child
Endothelium, Vascular pathology
Escherichia coli genetics
Escherichia coli pathogenicity
Escherichia coli Infections complications
Escherichia coli Infections microbiology
Genes, Bacterial
Hemolytic-Uremic Syndrome microbiology
Hemolytic-Uremic Syndrome pathology
Humans
Shiga Toxins classification
Shiga Toxins genetics
Shiga Toxins toxicity
Transcription, Genetic
Virulence genetics
Hemolytic-Uremic Syndrome etiology
Subjects
Details
- Language :
- English
- ISSN :
- 0094-6176
- Volume :
- 32
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Seminars in thrombosis and hemostasis
- Publication Type :
- Academic Journal
- Accession number :
- 16575685
- Full Text :
- https://doi.org/10.1055/s-2006-939766