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A case-control study investigating the role of sulfotransferase 1A1 polymorphism in head and neck cancer.
- Source :
-
Journal of cancer research and clinical oncology [J Cancer Res Clin Oncol] 2006 Jul; Vol. 132 (7), pp. 466-72. Date of Electronic Publication: 2006 Mar 31. - Publication Year :
- 2006
-
Abstract
- Purpose: Sulfotransferases (SULT) 1A1 detoxify and bio-activate a broad spectrum of substrates including xenobiotics. The SULT1A1 gene possesses a G-->A polymorphism that results in an Arg to His substitution at codon 213, with the His allele having a low activity. The purpose of this study was to evaluate whether SULT1A1 Arg213His polymorphisms are risk factors for head and neck squamous cell carcinoma (SCCHN).<br />Methods: A total of 124 consecutive primary SCCHN patients and 249 age- and sex-matched hospital controls were enrolled in this study. Genomic DNA was isolated from peripheral blood lymphocytes and genotyping was performed by PCR-RFLP. A comprehensive epidemiological interview was conducted on all participants to collect their lifestyle data.<br />Results: The His/His frequencies in cases and controls were 6.5% (8/123) and 3.6% (9/247), respectively (P=0.049). Multivariate logistic regression analysis showed a significant association of SCCHN and His/His genotype (OR=3.60; 95% CI=1.01-12.88). This association was stronger amongst older people, alcohol and low fruit consumers. The resulted SULT1A1 His/His genotype also associated with a higher risk of neck node positive status (OR=5.82; 95% CI=1.10-30.68).<br />Conclusions: These preliminary findings show for the first time that the SULT1A1 His (213) allele is a possible risk factor for head and neck cancer development.
- Subjects :
- Adenine
Alleles
Arginine
Arylsulfotransferase blood
Case-Control Studies
Codon
Female
Guanine
Histidine
Humans
Life Style
Male
Middle Aged
Risk Factors
Arylsulfotransferase genetics
Carcinoma, Squamous Cell enzymology
Carcinoma, Squamous Cell genetics
Head and Neck Neoplasms enzymology
Head and Neck Neoplasms genetics
Polymorphism, Genetic
Subjects
Details
- Language :
- English
- ISSN :
- 0171-5216
- Volume :
- 132
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Journal of cancer research and clinical oncology
- Publication Type :
- Academic Journal
- Accession number :
- 16575574
- Full Text :
- https://doi.org/10.1007/s00432-006-0093-9