The interval from surgery to chemotherapy in the treatment of advanced epithelial ovarian carcinoma.

Authors :: Rosa DD
Clamp A
Mullamitha S
Ton NC
Lau S
Byrd L
Clayton R
Slade RJ
Kitchener HC
Shanks JH
Wilson G
McVey R
Hasan J
Swindell R
Jayson GC
Source :: European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology [Eur J Surg Oncol] 2006 Jun; Vol. 32 (5), pp. 588-91. Date of Electronic Publication: 2006 Mar 29.
Publication Year :: 2006
Abstract: Background: To study the effect of the interval between surgery and the start of chemotherapy in the treatment of patients with advanced ovarian cancer.<br />Methods: We stratified patients according to the start of platinum-based chemotherapy in group 1 (within 4 weeks from surgery), group 2 (between 4 and 8 weeks) and group 3 (between 8 and 12 weeks).<br />Results: Three hundred and ninty-four stage III ovarian cancer patients were analysed. In the multivariate analysis there were no differences in survival according to the interval between surgery and chemotherapy among the three groups. The independent prognostic variables were type of procedure (p = 0.014), performance status (p = 0.040) and post-chemotherapy CA-125 (p < 0.0001).<br />Conclusions: The interval between surgery and chemotherapy does not affect outcome.

Language :: English
ISSN :: 0748-7983
Volume :: 32
Issue :: 5
Database :: MEDLINE
Journal :: European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
Publication Type :: Academic Journal
Accession number :: 16569491
Full Text :: https://doi.org/10.1016/j.ejso.2006.02.013

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