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[Identification strategy of RHCE gene variants at the National Blood Group Reference Laboratory: impact on transfusion safety].
- Source :
-
Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine [Transfus Clin Biol] 2006 Mar-Apr; Vol. 13 (1-2), pp. 13-8. Date of Electronic Publication: 2006 Mar 24. - Publication Year :
- 2006
-
Abstract
- The RH blood group is the most polymorphic and immunogenic blood group system. The RH locus is composed of 2 highly homologous genes: the RHD gene encoding the D polypeptide; and the RHCE gene, encoding C or c together with either E or e polypeptides. Numerous variants exist for both RHD and RHCE genes. Among them we were interested in the serological and molecular definition of numerous pre-published RHCE variants encountered in different populations. The identification of these variants is crucial to ensure the transfusion safety for patients expressing these variants. Here we propose a procedure to identify some of them and discuss the adequate transfusion strategy. This procedure has enable us to identify new variants to be presented at the symposium.
- Subjects :
- Blood Group Incompatibility prevention & control
Blood Grouping and Crossmatching standards
Ethnicity genetics
France
Gene Frequency
Genotype
Humans
Isoantibodies analysis
Isoantibodies blood
Models, Molecular
Rh-Hr Blood-Group System chemistry
Rh-Hr Blood-Group System classification
Rh-Hr Blood-Group System immunology
Rho(D) Immune Globulin
Blood Grouping and Crossmatching methods
Genetic Variation
Rh-Hr Blood-Group System genetics
Transfusion Reaction
Subjects
Details
- Language :
- French
- ISSN :
- 1246-7820
- Volume :
- 13
- Issue :
- 1-2
- Database :
- MEDLINE
- Journal :
- Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine
- Publication Type :
- Academic Journal
- Accession number :
- 16563835
- Full Text :
- https://doi.org/10.1016/j.tracli.2006.02.003