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Bioactive dammarane triterpenes from the mangrove plant Bruguiera gymnorrhiza.
- Source :
-
Journal of natural products [J Nat Prod] 2006 Mar; Vol. 69 (3), pp. 421-4. - Publication Year :
- 2006
-
Abstract
- Three new dammarane triterpenes, bruguierins A-C (1-3), were isolated from a petroleum ether extract of the flowers of Bruguiera gymnorrhiza. Their structures were determined on the basis of physical and spectroscopic data interpretation. With stably transfected HepG2 cells, the three isolates activated antioxidant response element (ARE luciferase activation) with EC(50) values of 7.8, 9.4, and 15.7 microM, respectively. Bruguierin A (1) also inhibited phorbol ester-induced NFkappaB (nuclear factor-kappaB) luciferase activation with an IC(50) value of 1.4 microM and selectively inhibited cyclooxygenase-2 (COX-2) activity with an IC(50) value of 0.37 microM. Compounds 2 and 3 were not active in these bioassays.
- Subjects :
- Inhibitory Concentration 50
Molecular Structure
Thailand
Dammaranes
Cyclooxygenase 2 Inhibitors chemistry
Cyclooxygenase 2 Inhibitors isolation & purification
Cyclooxygenase 2 Inhibitors pharmacology
Plants, Medicinal chemistry
Rhizophoraceae chemistry
Triterpenes chemistry
Triterpenes isolation & purification
Triterpenes pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0163-3864
- Volume :
- 69
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Journal of natural products
- Publication Type :
- Academic Journal
- Accession number :
- 16562850
- Full Text :
- https://doi.org/10.1021/np058112x