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Incidence of voriconazole hepatotoxicity during intravenous and oral treatment for invasive fungal infections.
- Source :
-
The Journal of antimicrobial chemotherapy [J Antimicrob Chemother] 2006 Jun; Vol. 57 (6), pp. 1248-50. Date of Electronic Publication: 2006 Mar 23. - Publication Year :
- 2006
-
Abstract
- Objectives: Absorption of oral voriconazole is good and in contrast to the intravenous (iv) formulation it can be given in patients with renal insufficiency. Furthermore, the acquisition costs are significantly lower. The aim of this study was to compare the incidence of hepatotoxicity in patients treated with the oral formulation of voriconazole with that in patients treated with the iv formulation.<br />Methods: This was a retrospective observational study. A total of 35 patients with haematological disease and an invasive fungal infection were treated with oral voriconazole during the entire regimen. We compared the incidence of hepatotoxicity with that in 11 patients treated intravenously during the first week.<br />Results: The incidence of increased liver enzymes was comparable between both groups. Voriconazole was discontinued in two patients in the oral group and one patient in the iv group because of hepatotoxicity. The incidence of liver enzyme elevations in the entire study cohort of 46 patients was higher than that previously reported in a comparable study population (P < 0.001). However, clinically significant hepatotoxicity was infrequently observed (3/46 or 6.5%).<br />Conclusions: In 35 patients with invasive fungal infections we instituted oral voriconazole therapy from day 1 and found an incidence of hepatotoxicity comparable to 11 controls treated intravenously.
- Subjects :
- Administration, Oral
Antifungal Agents administration & dosage
Antifungal Agents therapeutic use
Hematologic Diseases complications
Humans
Injections, Intravenous
Liver Function Tests
Pyrimidines administration & dosage
Pyrimidines therapeutic use
Retrospective Studies
Triazoles administration & dosage
Triazoles therapeutic use
Voriconazole
Antifungal Agents adverse effects
Liver drug effects
Mycoses drug therapy
Pyrimidines adverse effects
Triazoles adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 0305-7453
- Volume :
- 57
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- The Journal of antimicrobial chemotherapy
- Publication Type :
- Academic Journal
- Accession number :
- 16556632
- Full Text :
- https://doi.org/10.1093/jac/dkl108