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Two types of TNF receptors are expressed on human normal and malignant B lymphocytes.
- Source :
-
Clinical immunology and immunopathology [Clin Immunol Immunopathol] 1991 Nov; Vol. 61 (2 Pt 1), pp. 260-7. - Publication Year :
- 1991
-
Abstract
- We analyzed the expression of the 75- and 55-kDa tumor necrosis factor (TNF) receptors on the surface of human normal and malignant B cells. Freshly isolated tonsillar B cells do not express detectable amounts of receptors. After 24 hr of stimulation with anti-IgM and low-molecular-weight (l.m.w.) BCGF, B cells express the 75-kDa receptor but not the 55-kDa receptor, but after 48 hr of stimulation both types of receptors are expressed. Three of 10 patients with B-chronic lymphatic leukemia or hairy cell leukemia (HCL) had a small population of TNF receptor positive tumor cells; after in vitro stimulation of tumor cells in 10/10 patients various patterns of 75- and 55-kDa TNF receptor expression were found. MAb UTR-1, which binds the 75-kDa receptor, inhibits the l.m.w. BCGF-induced [3H]thymidine incorporation of cultured tonsillar B cells and HCL cells. This may provide evidence that in B cells the 75 kDa TNF receptor molecule is functionally active.
- Subjects :
- Antibodies, Monoclonal immunology
Cell Division
Cells, Cultured
Humans
Leukemia, Hairy Cell pathology
Leukemia, Lymphocytic, Chronic, B-Cell pathology
Lymphocyte Activation
Receptors, Cell Surface immunology
Receptors, Cell Surface physiology
Receptors, Tumor Necrosis Factor
B-Lymphocytes chemistry
Leukemia, Hairy Cell metabolism
Leukemia, Lymphocytic, Chronic, B-Cell metabolism
Receptors, Cell Surface analysis
Subjects
Details
- Language :
- English
- ISSN :
- 0090-1229
- Volume :
- 61
- Issue :
- 2 Pt 1
- Database :
- MEDLINE
- Journal :
- Clinical immunology and immunopathology
- Publication Type :
- Academic Journal
- Accession number :
- 1655323
- Full Text :
- https://doi.org/10.1016/s0090-1229(05)80029-7