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CD8+ T cells but not polymorphonuclear leukocytes are required to limit chronic oral carriage of Candida albicans in transgenic mice expressing human immunodeficiency virus type 1.
- Source :
-
Infection and immunity [Infect Immun] 2006 Apr; Vol. 74 (4), pp. 2382-91. - Publication Year :
- 2006
-
Abstract
- Candida albicans causes oropharyngeal candidiasis (OPC) but rarely disseminates to deep organs in human immunodeficiency virus (HIV) infection. Here, we used a model of OPC in CD4C/HIV(Mut) transgenic (Tg) mice to investigate the role of polymorphonuclear leukocytes (PMNs) and CD8+ T cells in limiting candidiasis to the mucosa. Numbers of circulating PMNs and their oxidative burst were both augmented in CD4C/HIV(MutA) Tg mice expressing rev, env, and nef of HIV type 1 (HIV-1), while phagocytosis and killing of C. albicans were largely unimpaired compared to those in non-Tg mice. Depletion of PMNs in these Tg mice did not alter oral or gastrointestinal burdens of C. albicans or cause systemic dissemination. However, oral burdens of C. albicans were increased in CD4C/HIV(MutG) Tg mice expressing only the nef gene of HIV-1 and bred on a CD8 gene-deficient background (CD8-/-), compared to control or heterozygous CD8+/- CD4C/HIV(MutG) Tg mice. Thus, CD8+ T cells contribute to the host defense against oral candidiasis in vivo, specifically in the context of nef expression in a subset of immune cells.
- Subjects :
- Animals
CD4 Antigens genetics
CD8 Antigens genetics
CD8-Positive T-Lymphocytes virology
Candidiasis, Oral genetics
Candidiasis, Oral virology
Cells, Cultured
Chronic Disease
Disease Models, Animal
Female
HIV Infections genetics
HIV Infections microbiology
Humans
Leukopenia genetics
Leukopenia immunology
Male
Mice
Mice, Inbred C3H
Mice, Knockout
Mice, Transgenic
Neutrophils virology
Phagocytosis genetics
Respiratory Burst genetics
Time Factors
CD8-Positive T-Lymphocytes immunology
CD8-Positive T-Lymphocytes microbiology
Candida albicans immunology
Candidiasis, Oral immunology
HIV Infections immunology
HIV-1 genetics
Neutrophils immunology
Neutrophils microbiology
Subjects
Details
- Language :
- English
- ISSN :
- 0019-9567
- Volume :
- 74
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Infection and immunity
- Publication Type :
- Academic Journal
- Accession number :
- 16552068
- Full Text :
- https://doi.org/10.1128/IAI.74.4.2382-2391.2006