Back to Search
Start Over
[Relationship between expression of cyclin D1, Ki-67 and bcl-2 and biologic behavior in CD117-positive gastrointestinal stromal tumors].
- Source :
-
Zhonghua bing li xue za zhi = Chinese journal of pathology [Zhonghua Bing Li Xue Za Zhi] 2005 Dec; Vol. 34 (12), pp. 788-90. - Publication Year :
- 2005
-
Abstract
- Objective: To investigate the clinicopathologic features of gastrointestinal stromal tumors (GISTs) and to identify reliable prognostic parameters.<br />Methods: Fifty-nine GISTs were studied by immunostaining of CD117, CD34, SMA, desmin, S-100, bcl-2, and Ki-67. Histopathologic evaluations included tumor size, necrosis, histological growth patterns, mitotic activities and tumor lymphocytic infiltrate. The patients were clinically followed for 2 to 9 years. Univariate, multivariate and correlative statistical evaluations were used to analyze the data.<br />Results: Among the 59 patients, 40 were alive and 15 died of their tumors at follow-up, the remaining 4 patients died of other causes. Pathological parameters that correlated with prognosis included tumor sizes of more than 5 cm, tumor tissue necrosis, mitotic cell count equal or higher than 5 per 50 high power field, Ki-67 labeling index (LI) equal or higher than 5% and intense bcl-2 immunostaining. Multivariate analysis showed that the mitotic count and Ki-67 LI were independent prognostic indicators. There was a correlation between mitotic count and Ki-67 LI.<br />Conclusions: Mitotic count and Ki-67 LI are the best predictors for a poor outcome of GIST after surgical treatment. Ki-67 immunostaining may substitute mitotic count as a useful prognostic parameter.
- Subjects :
- Adolescent
Adult
Aged
Child
Female
Follow-Up Studies
Gastrointestinal Stromal Tumors pathology
Humans
Male
Middle Aged
Prognosis
Cyclin D1 metabolism
Gastrointestinal Stromal Tumors metabolism
Ki-67 Antigen metabolism
Proto-Oncogene Proteins c-bcl-2 metabolism
Proto-Oncogene Proteins c-kit metabolism
Subjects
Details
- Language :
- Chinese
- ISSN :
- 0529-5807
- Volume :
- 34
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Zhonghua bing li xue za zhi = Chinese journal of pathology
- Publication Type :
- Academic Journal
- Accession number :
- 16545187