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[Genes involved in sex determination and differentiation].
- Source :
-
Arquivos brasileiros de endocrinologia e metabologia [Arq Bras Endocrinol Metabol] 2005 Feb; Vol. 49 (1), pp. 14-25. Date of Electronic Publication: 2006 Mar 16. - Publication Year :
- 2005
-
Abstract
- Chromosomal sex is established at fertilization by the presence of an X or Y chromosome. The first step of male and female development is gonadal specialization in testes or ovaries; all other processes that follow result from secondary effects produced by testis and ovary hormones. Gonadal determination and differentiation and the development of external genitalia involve time- and tissue-specific expression of genes forming a gene cascade. Those genes, their expression profile and their role in the pathological manifestations related to gonadal and external genitalia development will be discussed in this review.
Details
- Language :
- Portuguese
- ISSN :
- 0004-2730
- Volume :
- 49
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Arquivos brasileiros de endocrinologia e metabologia
- Publication Type :
- Academic Journal
- Accession number :
- 16544031
- Full Text :
- https://doi.org/10.1590/s0004-27302005000100004