Back to Search
Start Over
Antibody targeting of TIRC7 results in significant therapeutic effects on collagen-induced arthritis in mice.
- Source :
-
Clinical and experimental immunology [Clin Exp Immunol] 2006 Apr; Vol. 144 (1), pp. 142-51. - Publication Year :
- 2006
-
Abstract
- TIRC7 is a cell surface molecule which is expressed in T and B lymphocytes and negatively regulates their function. Anti-TIRC7 specific monoclonal antibody (mAb) inhibited T cell memory response to recall antigens. Up-regulation of TIRC7 on lymphocytes from joint tissue of patients with Rheumatoid Arthritis (RA) and mice with collagen induced arthritis (CIA) suggested TIRC7 as a novel target to promote anti-inflammatory reaction. Anti-TIRC7 mAb administration significantly inhibited the induction and progression of CIA and the anti-collagen IgG1 and IgG2a antibody response. Combination therapy of anti-TIRC7 mAb and soluble TNF-alpha receptor demonstrated an increased inhibitory effect over the single compounds on CIA. The results demonstrate the therapeutic potential of TIRC7 targeting with mAb in diseases associated with exaggerated T and B cell responses.
- Subjects :
- Animals
Arthritis, Experimental therapy
Arthritis, Rheumatoid immunology
Arthritis, Rheumatoid therapy
B-Lymphocytes immunology
Female
Humans
Immunoglobulin G immunology
Immunologic Memory immunology
Immunotherapy methods
Knee Joint immunology
Male
Mice
Mice, Inbred BALB C
Mice, Inbred DBA
Receptors, Tumor Necrosis Factor immunology
Synovial Fluid immunology
T-Lymphocytes immunology
Tumor Necrosis Factor-alpha immunology
Up-Regulation immunology
Antibodies, Monoclonal immunology
Arthritis, Experimental immunology
Vacuolar Proton-Translocating ATPases immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0009-9104
- Volume :
- 144
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Clinical and experimental immunology
- Publication Type :
- Academic Journal
- Accession number :
- 16542376
- Full Text :
- https://doi.org/10.1111/j.1365-2249.2006.03044.x