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Malignant histiocytosis of the brain in three dogs.
- Source :
-
Journal of comparative pathology [J Comp Pathol] 2006 Feb-Apr; Vol. 134 (2-3), pp. 241-4. Date of Electronic Publication: 2006 Mar 14. - Publication Year :
- 2006
-
Abstract
- Three dogs (two Rottweilers and a Flat-coated retriever) showed various neurological signs, including apathy, depression, circling, a partial decrease in functions associated with cranial nerves, seizures, hyperaesthesia, proprioceptive deficits, and increased spinal reflexes. In all three cases, necropsy revealed a solid, distinct, white mass in the brain and multiple, poorly demarcated, firm nodular proliferations in the lung; in one case the liver was also affected. Histopathological examination showed loosely aggregated, pleomorphic cells, with abundant eosinophilic cytoplasm. The neoplastic cells sometimes contained vacuoles or phagocytized cells. Binucleated and multinucleated giant cells, and mitotic figures, were common. Immunohistochemically, the tumour cells reacted strongly for lysozyme and vimentin, but there was no reaction for S-100 protein, cytokeratin, CD3 or CD79a. The histological and immunohistochemical examinations indicated a histiocytic origin of the tumour cells and malignant histiocytosis was therefore diagnosed.
- Subjects :
- Animals
Biomarkers, Tumor metabolism
Brain metabolism
Brain pathology
Brain Neoplasms pathology
Brain Neoplasms physiopathology
Dogs
Fatal Outcome
Female
Histiocytes metabolism
Histiocytes pathology
Histiocytic Sarcoma pathology
Histiocytic Sarcoma physiopathology
Immunohistochemistry veterinary
Male
Brain Neoplasms veterinary
Dog Diseases pathology
Histiocytic Sarcoma veterinary
Subjects
Details
- Language :
- English
- ISSN :
- 0021-9975
- Volume :
- 134
- Issue :
- 2-3
- Database :
- MEDLINE
- Journal :
- Journal of comparative pathology
- Publication Type :
- Academic Journal
- Accession number :
- 16537081
- Full Text :
- https://doi.org/10.1016/j.jcpa.2005.09.005