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Constraints on HIV-1 evolution and immunodominance revealed in monozygotic adult twins infected with the same virus.
- Source :
-
The Journal of experimental medicine [J Exp Med] 2006 Mar 20; Vol. 203 (3), pp. 529-39. Date of Electronic Publication: 2006 Mar 13. - Publication Year :
- 2006
-
Abstract
- The predictability of virus-host interactions and disease progression in rapidly evolving human viral infections has been difficult to assess because of host and genetic viral diversity. Here we examined adaptive HIV-specific cellular and humoral immune responses and viral evolution in adult monozygotic twins simultaneously infected with the same virus. CD4 T cell counts and viral loads followed similar trajectories over three years of follow up. The initial CD8 T cell response targeted 17 epitopes, 15 of which were identical in each twin, including two immunodominant responses. By 36 months after infection, 14 of 15 initial responses were still detectable in both, whereas all new responses were subdominant and remained so. Of four responses that declined in both twins, three demonstrated mutations at the same residue. In addition, the evolving antibody responses cross-neutralized the other twin's virus, with similar changes in the pattern of evolution in the envelope gene. These results reveal considerable concordance of adaptive cellular and humoral immune responses and HIV evolution in the same genetic environment, suggesting constraints on mutational pathways to HIV immune escape.
- Subjects :
- Adult
Antibodies, Viral blood
Antibodies, Viral immunology
CD4 Lymphocyte Count methods
CD8-Positive T-Lymphocytes immunology
Epitopes, T-Lymphocyte immunology
Female
Follow-Up Studies
Gene Products, env immunology
HIV Seropositivity blood
HIV Seropositivity immunology
HIV-1 immunology
Humans
Immunity, Cellular genetics
Immunity, Cellular immunology
Male
Amino Acid Substitution
Epitopes, T-Lymphocyte genetics
Evolution, Molecular
Gene Products, env genetics
HIV Seropositivity genetics
HIV-1 genetics
Point Mutation
Subjects
Details
- Language :
- English
- ISSN :
- 0022-1007
- Volume :
- 203
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- The Journal of experimental medicine
- Publication Type :
- Academic Journal
- Accession number :
- 16533886
- Full Text :
- https://doi.org/10.1084/jem.20052116