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Influence of serotonergic transmission anD postsynaptic 5-HT2C action on the feeding behavior of Coturnix japonica (Galliformes: Aves).

Authors :
Cedraz-Mercez PL
Almeida AC
Costa-e-Sousa RH
Badauê-Passos Júnior D
Castilhos LR
Olivares EL
Marinho Júnior A
Medeiros MA
Reis LC
Source :
Brazilian journal of biology = Revista brasleira de biologia [Braz J Biol] 2005 Nov; Vol. 65 (4), pp. 589-95.
Publication Year :
2005

Abstract

We investigated the role of 5-HT2C receptors and serotonergic transmission in the feeding behavior control of quails. Administration of serotonin releaser, fenfluramine (FEN) and 5-HT2C agonists, mCPP and MK212, 1.0 and 3.3 mg/Kg induced significant inhibition of food intake in previously fasted fowls (0.71 +/- 0.18 g and 0.47 +/- 0.2 g; 0.49 +/- 0.22 g and 0.48 +/- 0.29 g; 0.82 +/- 0.13 g and 0.71 +/- 0.16 g, respectively). Control groups ranged from 2.89 +/- 0.21 g to 2.97 +/- 0.22 g, 60 min after reintroduction of food, P < 0.0001). Similar results were obtained with normally fed quails. Both serotonin releaser and 5-HT2C agonists, in a 3.3 mg/Kg dose, induced hypophagy (FEN, 0.78 +/- 0.08 g; mCPP, 0.89 +/- 0.07 g; MK212, 1.25 +/- 0.17 g vs. controls, 2.05 +/- 0.12 g, 120 min after food was presented, P < 0.0001 to P < 0.01). Previous administration of 5-HT2C antagonist, LY53857 (5.0 mg/Kg) blocked the hypophagic response induced by 5-HT2C agonists 60 min after food was reintroduced. Current data show a modulatory role of serotonin release and postsynaptic 5-HT2C receptors in the feeding behavior of quails.

Details

Language :
English
ISSN :
1519-6984
Volume :
65
Issue :
4
Database :
MEDLINE
Journal :
Brazilian journal of biology = Revista brasleira de biologia
Publication Type :
Academic Journal
Accession number :
16532182
Full Text :
https://doi.org/10.1590/s1519-69842005000400005