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Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis.
- Source :
-
Cancer cell [Cancer Cell] 2006 Mar; Vol. 9 (3), pp. 157-73. - Publication Year :
- 2006
-
Abstract
- Previously undescribed prognostic subclasses of high-grade astrocytoma are identified and discovered to resemble stages in neurogenesis. One tumor class displaying neuronal lineage markers shows longer survival, while two tumor classes enriched for neural stem cell markers display equally short survival. Poor prognosis subclasses exhibit markers either of proliferation or of angiogenesis and mesenchyme. Upon recurrence, tumors frequently shift toward the mesenchymal subclass. Chromosomal locations of genes distinguishing tumor subclass parallel DNA copy number differences between subclasses. Functional relevance of tumor subtype molecular signatures is suggested by the ability of cell line signatures to predict neurosphere growth. A robust two-gene prognostic model utilizing PTEN and DLL3 expression suggests that Akt and Notch signaling are hallmarks of poor prognosis versus better prognosis gliomas, respectively.
- Subjects :
- Brain growth & development
Brain Neoplasms pathology
Disease Progression
Gene Dosage
Gene Expression Profiling
Gene Expression Regulation, Neoplastic
Glioma pathology
Humans
In Situ Hybridization
Intracellular Signaling Peptides and Proteins
Membrane Proteins biosynthesis
Membrane Proteins genetics
Neoplasm Invasiveness genetics
Oligonucleotide Array Sequence Analysis
PTEN Phosphohydrolase biosynthesis
PTEN Phosphohydrolase genetics
Polymerase Chain Reaction
Prognosis
Biomarkers, Tumor analysis
Brain Neoplasms classification
Brain Neoplasms genetics
Gene Expression
Glioma classification
Glioma genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1535-6108
- Volume :
- 9
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Cancer cell
- Publication Type :
- Academic Journal
- Accession number :
- 16530701
- Full Text :
- https://doi.org/10.1016/j.ccr.2006.02.019