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5-Piperazinyl pyridine carboxamide bradykinin B1 antagonists.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2006 May 15; Vol. 16 (10), pp. 2791-5. Date of Electronic Publication: 2006 Mar 10. - Publication Year :
- 2006
-
Abstract
- A series of 2,3-diaminopyridine bradykinin B(1) antagonists was modified to mitigate the potential for bioactivation. Removal of the 3-amino group and incorporation of basic 5-piperazinyl carboxamides at the pyridine 5-position provided compounds with high affinity for the human B(1) receptor.
Details
- Language :
- English
- ISSN :
- 0960-894X
- Volume :
- 16
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 16529929
- Full Text :
- https://doi.org/10.1016/j.bmcl.2006.01.112