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[Bile duct necrosis and hepatic necrosis following hepatic arterial infusion chemotherapy].
- Source :
-
Gan to kagaku ryoho. Cancer & chemotherapy [Gan To Kagaku Ryoho] 1991 Aug; Vol. 18 (11), pp. 1856-9. - Publication Year :
- 1991
-
Abstract
- Three cases of bile duct necrosis owing to hepatic arterial infusion chemotherapy (HAI) were reported. Regarding HAI, transcatheter hepatic arterial embolization (TAE) was applied in two cases (hepatocellular carcinoma: 1; metastasis: 1) and 5-fluorouracil (continuous) combined with leucovorin (one shot) therapy (LV + 5-FU) was given to one metastatic case. In the data of blood biochemistry, serum alkaline phosphatase, gamma-glutamyl transpeptidase, and leucine aminopeptidase values characteristically elevated without the elevation of total bilirubin value. Hepatic tumors degenerated with necrosis in all cases and no viable cells were histologically recognized. Although the destruction of bile ducts was locally detected adjacent to these tumors in TAE cases and was more widespread in the LV + 5-FU case, these lesions were very similar in each case. Therefore, we concluded that both ischemia and drug toxicity induced bile duct necrosis and the necrosis around the bile duct was the secondary change due to the leaked bile juice.
- Subjects :
- Aged
Fluorouracil administration & dosage
Fluorouracil adverse effects
Hepatic Artery
Humans
Infusion Pumps, Implantable
Leucovorin administration & dosage
Leucovorin adverse effects
Male
Middle Aged
Necrosis chemically induced
Antineoplastic Combined Chemotherapy Protocols adverse effects
Bile Ducts, Intrahepatic pathology
Carcinoma, Hepatocellular drug therapy
Embolization, Therapeutic adverse effects
Infusions, Intra-Arterial adverse effects
Liver pathology
Liver Neoplasms drug therapy
Subjects
Details
- Language :
- Japanese
- ISSN :
- 0385-0684
- Volume :
- 18
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Gan to kagaku ryoho. Cancer & chemotherapy
- Publication Type :
- Academic Journal
- Accession number :
- 1652226