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Differential effects of anxiogenic central and peripheral benzodiazepine receptor ligands in tests of learning and memory.
- Source :
-
Psychopharmacology [Psychopharmacology (Berl)] 1991; Vol. 104 (2), pp. 249-54. - Publication Year :
- 1991
-
Abstract
- Previous research has demonstrated that low doses of anxiogenic central benzodiazepine receptor (CBR) ligands, the beta-carbolines, improve performance in various learning and memory tests in animals if administered prior to training. The present experiments compared the effect of a beta-carboline (FG 7142) with that of a pharmacologically distinct anxiogenic compound, a peripheral benzodiazepine receptor (PBR) ligand, 4'-chlorodiazepam (Ro5-4864), in two tests of learning and memory in rats. As expected, FG 7142 significantly improved performance in a passive avoidance test. Ro5-4864 was without effect. In a shuttlebox escape test, Ro5-4864 significantly impaired performance while FG 7142 had no effect. The effect of Ro5-4864 was antagonized by the specific peripheral benzodiazepine receptor antagonist, PK 11195. These results indicate that the differential impact of CBR and PBR anxiogenic ligands on performance in aversively-motivated learning tests may be a reflection of their distinct pharmacologies.
- Subjects :
- Animals
Avoidance Learning drug effects
Benzodiazepinones pharmacology
Carbolines pharmacology
Conditioning, Operant drug effects
Isoquinolines pharmacology
Ligands
Male
Rats
Rats, Inbred Strains
Reaction Time drug effects
Anxiety psychology
Learning drug effects
Memory drug effects
Receptors, GABA-A drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 0033-3158
- Volume :
- 104
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Psychopharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 1652145
- Full Text :
- https://doi.org/10.1007/BF02244187