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Comparison of ticlopidine vs. clopidogrel in addition to aspirin after paclitaxel-eluting stent implantation: insights from the TRUE (Taxusin Real-life Usage Evaluation) Study.
- Source :
-
International journal of cardiology [Int J Cardiol] 2006 Apr 14; Vol. 108 (3), pp. 406-7. - Publication Year :
- 2006
-
Abstract
- Thienopyridines and aspirin are beneficial in patients undergoing bare-metal stent implantation, and aspirin and clopidogrel treatment have also been proved effective after drug-eluting stent (DES) implantation. However, despite the common substitution of clopidogrel with ticlopidine because of cost or patient intolerance, there are no data on the comparison of ticlopidine vs. clopidogrel after DES implantation. We hereby compare ticlopidine vs. clopidogrel after paclitaxel-eluting stent implantation in subjects enrolled in the prospective multicenter Taxus in Real-life Usage Evaluation (TRUE) Study. Across the 505 analyzed patients (112 treated with ticlopidine and 393 with clopidogrel), similar rates of early and mid-term (7 months) adverse thrombotic events were found with either antiplatelet regimen, with the notable exception of 2 cases of late stent thrombosis in patients who had prematurely withdrawn ticlopidine treatment just 3 months after the procedure. These findings thus support the overall safety and effectiveness of ticlopidine after DES implantation, and also confirm the increased risk of late thrombosis when premature withdrawal of thienopyridines occurs.
- Subjects :
- Clopidogrel
Coronary Restenosis prevention & control
Female
Humans
Male
Middle Aged
Multicenter Studies as Topic
Stents
Treatment Outcome
Aspirin therapeutic use
Coronary Disease therapy
Paclitaxel administration & dosage
Platelet Aggregation Inhibitors therapeutic use
Ticlopidine analogs & derivatives
Ticlopidine therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 0167-5273
- Volume :
- 108
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- International journal of cardiology
- Publication Type :
- Report
- Accession number :
- 16520130
- Full Text :
- https://doi.org/10.1016/j.ijcard.2005.03.038