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Effect of statin treatment on coronary collateral development in patients with diabetes mellitus.
- Source :
-
The American journal of cardiology [Am J Cardiol] 2006 Mar 15; Vol. 97 (6), pp. 772-4. Date of Electronic Publication: 2006 Jan 25. - Publication Year :
- 2006
-
Abstract
- Coronary collateral development is an important compensatory mechanism in advanced coronary artery disease, and patients with diabetes mellitus have impaired coronary collateral development. This study tested the hypothesis that statin treatment may increase coronary collateral development in patients with diabetes mellitus. The study population consisted of 149 consecutive diabetic patients who underwent clinically indicated coronary angiography and had >95% stenosis of > or =1 major coronary artery. Clinical information, including age, gender, history of hypertension, smoking, myocardial infarction, clinical presentation, and medications, was recorded before coronary angiography. Coronary collaterals were graded according to the Cohen-Rentrop method. Collateral grading was classified as poor when the collateral grade was 0 to 1 and good when it was 2 to 3. Among 149 patients (85 men; mean age 62 +/- 10 years), 74 (56%) were receiving statin treatment. In multivariate analysis, among demographic, clinical, and angiographic parameters, only statin therapy (odds ratio 3, 95% confidence interval 1.5 to 6.03, p = 0.002) and stable angina pectoris (odds ratio 3.24, 95% confidence interval 1.42 to 7.41, p = 0.005) were found to be independent predictors of better collateral formation. In conclusion, stable angina pectoris and statin treatment are associated with better coronary collateral development in patients with diabetes mellitus.
- Subjects :
- Angina Pectoris physiopathology
Atorvastatin
Cholesterol, LDL blood
Coronary Angiography
Female
Heptanoic Acids pharmacology
Heptanoic Acids therapeutic use
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors pharmacology
Male
Middle Aged
Multivariate Analysis
Odds Ratio
Pravastatin pharmacology
Pravastatin therapeutic use
Pyrroles pharmacology
Pyrroles therapeutic use
Retrospective Studies
Simvastatin pharmacology
Simvastatin therapeutic use
Collateral Circulation drug effects
Coronary Disease drug therapy
Coronary Disease physiopathology
Diabetes Mellitus drug therapy
Diabetes Mellitus physiopathology
Hydroxymethylglutaryl-CoA Reductase Inhibitors therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 0002-9149
- Volume :
- 97
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- The American journal of cardiology
- Publication Type :
- Academic Journal
- Accession number :
- 16516573
- Full Text :
- https://doi.org/10.1016/j.amjcard.2005.09.124