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[3H]hemicholinium-3 binding in rats with status epilepticus induced by lithium chloride and pilocarpine.
- Source :
-
European journal of pharmacology [Eur J Pharmacol] 1991 Apr 03; Vol. 195 (3), pp. 395-7. - Publication Year :
- 1991
-
Abstract
- The specific binding of [3H]hemicholinium-3 ([3H]HCh-3) and high-affinity [3H]choline uptake were measured in rats with status epilepticus induced by lithium and pilocarpine. The specific binding of [3H]HCh-3 in cortex and hippocampus from rats with status epilepticus increased to 2- to 3-fold of control while the striatal [3H]HCh-3 binding increased minimally. Scatchard analyses revealed that the observed changes resulted from an increase in Bmax of [3H]HCh-3 binding. High-affinity [3H]choline uptake remained unchanged. These results further implicate phospholipase A2 in the regulation of [3H]HCh-3 binding sites.
- Subjects :
- Acetylcholine metabolism
Animals
Cerebral Cortex drug effects
Cerebral Cortex metabolism
Choline metabolism
Hippocampus drug effects
Hippocampus metabolism
Kinetics
Lithium Chloride
Male
Rats
Rats, Inbred Strains
Seizures chemically induced
Seizures prevention & control
Status Epilepticus drug therapy
Chlorides therapeutic use
Hemicholinium 3 metabolism
Lithium therapeutic use
Pilocarpine therapeutic use
Status Epilepticus metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0014-2999
- Volume :
- 195
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- European journal of pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 1651249
- Full Text :
- https://doi.org/10.1016/0014-2999(91)90481-5