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Sodium excretion as a modulator of genetic associations with cardiovascular phenotypes in the European Project on Genes in Hypertension.
- Source :
-
Journal of hypertension [J Hypertens] 2006 Feb; Vol. 24 (2), pp. 235-42. - Publication Year :
- 2006
-
Abstract
- Hypertension is a chronic age-related disorder, affecting nearly 20% of all adult Europeans. This disease entails debilitating cardiovascular complications and is the leading cause for drug prescriptions in Europeans older than 50 years. Intensive research over the past two decades has so far failed to identify common genetic polymorphisms with a major impact on blood pressure or associated cardiovascular phenotypes, suggesting that multiple genes each with a minor impact, along with gene-gene and gene-environment interactions, play a role. The European Project on Genes in Hypertension (EPOGH) is a large-scale, family-based study in which participants from seven different populations were phenotyped and genotyped according to standardized procedures. This review article summarizes the initial 5-year findings and puts these observations into perspective against other published studies. The EPOGH demonstrated that phenotype-genotype relations strongly depend on host factors such as gender and lifestyle, in particular salt intake as reflected by the 24-h urinary excretion of sodium. The EPOGH therefore highlights the concept that phenotype-genotype relations can only be studied within a defined ecogenetic context.
- Subjects :
- Blood Pressure
Calmodulin-Binding Proteins genetics
Cytochrome P-450 CYP11B2 genetics
Heart Rate
Humans
Hypertrophy, Left Ventricular genetics
Ouabain blood
Peptidyl-Dipeptidase A genetics
Phenotype
Polymorphism, Genetic
Receptor, Angiotensin, Type 1 genetics
Hypertension genetics
Sodium urine
Subjects
Details
- Language :
- English
- ISSN :
- 0263-6352
- Volume :
- 24
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Journal of hypertension
- Publication Type :
- Academic Journal
- Accession number :
- 16508563
- Full Text :
- https://doi.org/10.1097/01.hjh.0000194115.89356.bd