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Persistence of autoreactive myelin oligodendrocyte glycoprotein (MOG)-specific T cell repertoires in MOG-expressing mice.
- Source :
-
European journal of immunology [Eur J Immunol] 2006 Mar; Vol. 36 (3), pp. 533-43. - Publication Year :
- 2006
-
Abstract
- Experimental autoimmune encephalomyelitis, an experimental murine model for multiple sclerosis, is induced by stimulation of myelin-specific T lymphocytes. Myelin oligodendrocyte glycoprotein (MOG), a minor component of myelin proteins, is a potent autoantigen which contributes extensively to the anti-myelin response. In the present work, immunoscope analyses and sequencing of the oligoclonal expansions revealed anti-MOG Valpha and Vbeta public repertoires in lymphocytes infiltrating the CNS of wild-type (WT) mice. Moreover, a subset of CNS-infiltrating CD4+ T lymphocytes bearing the public Vbeta8.2 segment have an inflammatory phenotype strongly suggesting that it is encephalitogenic. We then observed that, in lymph node cells of MOG-deficient and WT animals, the Valpha and Vbeta public repertoires expressed by MOG-specific T cells are identical in both strains of mice and correspond to those found in the CNS of WT animals. These findings indicate that the MOG immunodominant determinant is unable to induce tolerance by deletion, and public anti-MOG T cell repertoires are selected for, regardless of the presence of MOG in the thymus and peripheral organs.
- Subjects :
- Animals
Autoantigens genetics
Central Nervous System immunology
Disease Models, Animal
Encephalomyelitis, Autoimmune, Experimental genetics
Immune Tolerance genetics
Immune Tolerance immunology
Inflammation genetics
Inflammation immunology
Lymph Nodes immunology
Mice
Mice, Knockout
Multiple Sclerosis genetics
Myelin Proteins
Myelin-Associated Glycoprotein genetics
Myelin-Oligodendrocyte Glycoprotein
Species Specificity
Thymus Gland immunology
Autoantigens immunology
CD4-Positive T-Lymphocytes immunology
Encephalomyelitis, Autoimmune, Experimental immunology
Multiple Sclerosis immunology
Myelin-Associated Glycoprotein immunology
Receptors, Antigen, T-Cell, alpha-beta immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0014-2980
- Volume :
- 36
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- European journal of immunology
- Publication Type :
- Academic Journal
- Accession number :
- 16506290
- Full Text :
- https://doi.org/10.1002/eji.200535021