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Efficacy of topical cyclosporin 0.05% in the treatment of posterior blepharitis.
- Source :
-
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics [J Ocul Pharmacol Ther] 2006 Feb; Vol. 22 (1), pp. 47-53. - Publication Year :
- 2006
-
Abstract
- We assessed the efficacy of topical cyclosporin 0.05% ophthalmic emulsion versus tobramycin 0.3%/dexamethasone 0.1% in patients with posterior blepharitis. Posterior blepharitis improved significantly from the initial study visit with both cyclosporin treatment and tobramycin/dexamethasone. Cyclosporin provided greater improvements in Schirmer's scores (P < 0.001) and tear break-up time (P = 0.018) than tobramycin/dexamethasone after 12 weeks of treatment. Eyelid health also improved in both groups, but the mean improvement in meibomian gland secretion quality was significantly greater with cyclosporin than with tobramycin/dexamethasone (P = 0.015). Moreover, a higher percentage of patients in the cyclosporin treatment group had improvements in symptoms of blurred vision, burning, and itching and more cyclosporin-treated patients experienced resolution of lid telangiectasia. The findings in this prospective study suggest that posterior blepharitis can be more effectively treated with cyclosporin than with tobramycin/dexamethasone. These findings should be further evaluated in large-scale, controlled, clinical trials.
- Subjects :
- Administration, Topical
Anti-Bacterial Agents therapeutic use
Anti-Inflammatory Agents therapeutic use
Blepharitis pathology
Dexamethasone therapeutic use
Female
Humans
Immunosuppressive Agents
Male
Middle Aged
Ophthalmic Solutions
Prospective Studies
Tears metabolism
Tobramycin therapeutic use
Treatment Outcome
Blepharitis drug therapy
Cyclosporine administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 1080-7683
- Volume :
- 22
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics
- Publication Type :
- Academic Journal
- Accession number :
- 16503775
- Full Text :
- https://doi.org/10.1089/jop.2006.22.47