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Impact of quorum sensing on fitness of Pseudomonas aeruginosa.
- Source :
-
International journal of medical microbiology : IJMM [Int J Med Microbiol] 2006 Apr; Vol. 296 (2-3), pp. 93-102. Date of Electronic Publication: 2006 Feb 28. - Publication Year :
- 2006
-
Abstract
- In Pseudomonas aeruginosa, cell-cell communication based on N-acyl-homoserine lactone (AHL) signal molecules (termed quorum sensing) is known to control the production of extracellular virulence factors. Hence, in pathogenic interactions with host organisms, the quorum-sensing (QS) machinery can confer a selective advantage on P. aeruginosa. However, as shown by transcriptomic and proteomic studies, many intracellular metabolic functions are also regulated by quorum sensing. Some of these serve to regenerate the AHL precursors methionine and S-adenosyl-methionine and to degrade adenosine via inosine and hypoxanthine. The fact that a significant percentage of clinical and environmental isolates of P. aeruginosa is defective for QS because of mutation in the major QS regulatory gene lasR, raises the question of whether the QS machinery can have a negative impact on the organism's fitness. In vitro, lasR mutants have a higher probability to escape lytic death in stationary phase under alkaline conditions than has the QS-proficient wild type. Similar selective forces might also operate in natural environments.
- Subjects :
- 4-Butyrolactone physiology
Bacterial Proteins genetics
Cell Communication
DNA-Binding Proteins genetics
Deoxyadenosines metabolism
Humans
Pseudomonas Infections microbiology
Pseudomonas aeruginosa genetics
Thionucleosides metabolism
Trans-Activators genetics
Virulence
4-Butyrolactone analogs & derivatives
Pseudomonas aeruginosa pathogenicity
Pseudomonas aeruginosa physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1438-4221
- Volume :
- 296
- Issue :
- 2-3
- Database :
- MEDLINE
- Journal :
- International journal of medical microbiology : IJMM
- Publication Type :
- Academic Journal
- Accession number :
- 16503417
- Full Text :
- https://doi.org/10.1016/j.ijmm.2006.01.043