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Plasma immunoreactive melanotrophic hormones in patients on maintenance haemodialysis.
- Source :
-
British medical journal [Br Med J] 1975 Mar 22; Vol. 1 (5959), pp. 656-7. - Publication Year :
- 1975
-
Abstract
- Circulating levels of melanotrophic horomones and ACTH were determined in patients treated by maintenance dialysis for chronic renal failure. Plasma melanotrophic hormone levels were greatly increased in all patients studied (125-1100 ng/1 as compared with 12-36 ng/1 in normal adults) and were correlated with the duration of treatment. Skin pigmentation, especially in exposed areas, was notably increased, particularly in those patients with the highest plasma melanotrophic concentrations. Plasma ACTH levels were normal or only slightly raised and circulating corticosteroid concentrations, as determined by a fluorimetric method, all lay within the physiological range. The dissociation between ACTH and melanotrophic hormone levels in these patients may have been the result of a slower metabolic clearance of the latter.
- Subjects :
- Adolescent
Adrenal Cortex Hormones blood
Adrenocorticotropic Hormone blood
Adult
Chronic Disease
Female
Fluorometry
Humans
Kidney Failure, Chronic physiopathology
Kidney Failure, Chronic therapy
Male
Middle Aged
Radioimmunoassay
Skin Pigmentation
Kidney Failure, Chronic blood
Melanocyte-Stimulating Hormones blood
Renal Dialysis
Subjects
Details
- Language :
- English
- ISSN :
- 0007-1447
- Volume :
- 1
- Issue :
- 5959
- Database :
- MEDLINE
- Journal :
- British medical journal
- Publication Type :
- Academic Journal
- Accession number :
- 164974
- Full Text :
- https://doi.org/10.1136/bmj.1.5959.656