Back to Search Start Over

Disseminated Kikuchi-Fujimoto disease: a case report.

Authors :
Mseddi S
Makni S
Elloumi M
Boudawara T
Frikha M
Souissi T
Source :
Joint bone spine [Joint Bone Spine] 2006 May; Vol. 73 (3), pp. 311-3. Date of Electronic Publication: 2006 Jan 04.
Publication Year :
2006

Abstract

Subacute necrotizing lymphadenitis or Kikuchi-Fujimoto disease is a benign pathological entity diagnosed chiefly in young adults. We report a case in a 20-year-old woman who presented with swollen lymph nodes and a fever. Disseminated lymphadenopathy with nodes measuring up to 6 cm in diameter was found upon physical examination. The erythrocyte sedimentation rate was elevated to 40 mm/h and the lactic dehydrogenase level to 593 IU/l. Findings were negative from serological tests for rubella, hepatitis B, hepatitis C, HIV, and toxoplasmosis, as well as from tests for tuberculosis. A biopsy of a cervical lymph node showed nonsuppurative necrosis, karyorrhexis, and a marked histiocytic reaction consistent with Kikuchi-Fujimoto disease. No treatment was given, and a full recovery was achieved within 3 months. In this patient, the disseminated lymphadenopathy and constitutional symptoms strongly suggested a hematological malignancy and more specifically a lymphoproliferative disease.

Details

Language :
English
ISSN :
1297-319X
Volume :
73
Issue :
3
Database :
MEDLINE
Journal :
Joint bone spine
Publication Type :
Academic Journal
Accession number :
16495107
Full Text :
https://doi.org/10.1016/j.jbspin.2004.12.015