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Infections during induction therapy of childhood acute lymphoblastic leukemia--no association to mannose-binding lectin deficiency.
- Source :
-
European journal of haematology [Eur J Haematol] 2006 Jun; Vol. 76 (6), pp. 481-7. Date of Electronic Publication: 2006 Feb 23. - Publication Year :
- 2006
-
Abstract
- Objectives: Infection during the induction phase of childhood acute lymphoblastic leukemia (ALL) is a major cause of morbidity and mortality. Several studies have indicated that genetically determined low serum levels of mannose-binding lectin (MBL), a component of innate immunity, are associated with increased risk for infections in patients receiving chemotherapy. Thus, these patients have been proposed to be candidates for MBL replacement therapy.<br />Methods: In a population-based cohort of 137 children with ALL treated at a single pediatric hematology-oncology center with an almost identical chemotherapy regimen, we studied the relationship between polymorphisms in the MBL gene (MBL2) and the MBL2 promoter and the risk of infections during the first 50 d of induction therapy.<br />Results: No increased frequency of infection was seen for the children with genotypes encoding serum low levels of MBL. A higher incidence of fever (P < 0.004), infectious events (P = 0.025), days with neutropenia (P < 0.001) and a higher frequency of antimicrobial therapy (P = 0.0007) were seen in the young age group (<2.5 yr) compared with the older age group (> or =2.5 yr), independent of the MBL genotype.<br />Conclusions: MBL deficiency did not influence the frequency of infections in children receiving induction chemotherapy for ALL, not even in the youngest children (<2.5 yr) whom we found to have the highest risk for infections.
- Subjects :
- Adolescent
Age Factors
Allopurinol administration & dosage
Anti-Infective Agents therapeutic use
Antineoplastic Combined Chemotherapy Protocols adverse effects
Bacteremia epidemiology
Bacteremia etiology
Candidiasis epidemiology
Candidiasis etiology
Child
Child, Preschool
Cohort Studies
Disease Susceptibility
Doxorubicin administration & dosage
Female
Fever epidemiology
Fungemia epidemiology
Fungemia etiology
Genotype
Humans
Immunity, Innate
Immunocompromised Host
Incidence
Infant
Infections drug therapy
Infections etiology
Male
Mannose-Binding Lectin genetics
Neutropenia chemically induced
Neutropenia complications
Precursor Cell Lymphoblastic Leukemia-Lymphoma complications
Precursor Cell Lymphoblastic Leukemia-Lymphoma immunology
Precursor Cell Lymphoblastic Leukemia-Lymphoma metabolism
Prednisolone administration & dosage
Promoter Regions, Genetic
Remission Induction
Vincristine administration & dosage
Antineoplastic Combined Chemotherapy Protocols therapeutic use
Infections epidemiology
Mannose-Binding Lectin deficiency
Precursor Cell Lymphoblastic Leukemia-Lymphoma drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 0902-4441
- Volume :
- 76
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- European journal of haematology
- Publication Type :
- Academic Journal
- Accession number :
- 16494622
- Full Text :
- https://doi.org/10.1111/j.1600-0609.2006.00632.x