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Intraluminal injection of short chain fatty acids diminishes intestinal mucosa injury in experimental ischemia-reperfusion.
- Source :
-
Acta cirurgica brasileira [Acta Cir Bras] 2006 Jan-Feb; Vol. 21 (1), pp. 21-5. Date of Electronic Publication: 2006 Feb 13. - Publication Year :
- 2006
-
Abstract
- Purpose: Investigated the effect of intraluminal short-chain fatty acids (SCFA) on the intestinal mucosa in the presence of ischemia-reperfusion injury (IRI).<br />Methods: Six blind sacs of the small bowel (3 at the jejunum and 3 at the ileum) were created in ten Wistar rats. The lateral sacs of both bowel regions were subjected to IRI (15/15 minutes) while the medial sacs were let free to receive blood supply. In the lateral sacs, it was injected either a solution containing SCFA (butyrate, propionate and acetate) or pure saline at the bowel lumen. No fluid was injected in the medial sacs.<br />Results: Both at the jejunum and at the ileum the score of the mucosal injury was higher in saline than in control sacs. SCFA treated sacs showed lesser score at the ileum (p = 0.03) but were not significantly different at the jejunum (p = 0.83) when compared with saline sacs. It was found a significant greater number of neutrophils (p < 0.01) in the sacs treated with saline than in the other two sacs in both regions.<br />Conclusion: SCFA protect the distal small bowel mucosa and diminishes infiltration of neutrophils to the gut lamina propria in IRI.
- Subjects :
- Animals
Disease Models, Animal
Ileum blood supply
Intestinal Mucosa injuries
Jejunum blood supply
Leukocyte Count
Neutrophils drug effects
Random Allocation
Rats
Rats, Wistar
Reperfusion Injury blood
Fatty Acids, Volatile therapeutic use
Ileum drug effects
Intestinal Mucosa drug effects
Jejunum drug effects
Reperfusion Injury drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 0102-8650
- Volume :
- 21
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Acta cirurgica brasileira
- Publication Type :
- Academic Journal
- Accession number :
- 16491218
- Full Text :
- https://doi.org/10.1590/s0102-86502006000100006