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Intraluminal injection of short chain fatty acids diminishes intestinal mucosa injury in experimental ischemia-reperfusion.

Authors :
Aguilar-Nascimento JE
Salomão AB
Nochi RJ Jr
Nascimento M
Neves Jde S
Source :
Acta cirurgica brasileira [Acta Cir Bras] 2006 Jan-Feb; Vol. 21 (1), pp. 21-5. Date of Electronic Publication: 2006 Feb 13.
Publication Year :
2006

Abstract

Purpose: Investigated the effect of intraluminal short-chain fatty acids (SCFA) on the intestinal mucosa in the presence of ischemia-reperfusion injury (IRI).<br />Methods: Six blind sacs of the small bowel (3 at the jejunum and 3 at the ileum) were created in ten Wistar rats. The lateral sacs of both bowel regions were subjected to IRI (15/15 minutes) while the medial sacs were let free to receive blood supply. In the lateral sacs, it was injected either a solution containing SCFA (butyrate, propionate and acetate) or pure saline at the bowel lumen. No fluid was injected in the medial sacs.<br />Results: Both at the jejunum and at the ileum the score of the mucosal injury was higher in saline than in control sacs. SCFA treated sacs showed lesser score at the ileum (p = 0.03) but were not significantly different at the jejunum (p = 0.83) when compared with saline sacs. It was found a significant greater number of neutrophils (p < 0.01) in the sacs treated with saline than in the other two sacs in both regions.<br />Conclusion: SCFA protect the distal small bowel mucosa and diminishes infiltration of neutrophils to the gut lamina propria in IRI.

Details

Language :
English
ISSN :
0102-8650
Volume :
21
Issue :
1
Database :
MEDLINE
Journal :
Acta cirurgica brasileira
Publication Type :
Academic Journal
Accession number :
16491218
Full Text :
https://doi.org/10.1590/s0102-86502006000100006