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The relationship of insulin-like growth factor-II, insulin-like growth factor binding protein-3, and estrogen receptor-alpha expression to disease progression in epithelial ovarian cancer.
- Source :
-
Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2006 Feb 15; Vol. 12 (4), pp. 1208-14. - Publication Year :
- 2006
-
Abstract
- Purpose: The insulin-like growth factor (IGF) system plays important roles in cancer; blocking IGF signaling has been shown to have therapeutic effects on tumor growth. Many studies have focused on the effect of IGF-I, but few have addressed IGF-II. To assess the role of IGF-II in cancer, we analyzed IGF-II expression in ovarian cancer and examined its association with disease characteristics and prognosis.<br />Experimental Design: Included in the study were 215 patients with primary epithelial ovarian cancer. Fresh tumor specimens were collected during surgery, and the patients were followed for a median of 31 months. Total RNA was extracted from the tumor and analyzed for IGF-II, IGF binding protein 3 (IGFBP-3), and estrogen receptor-alpha expressions using quantitative reverse transcription PCR. Survival analysis was done to examine the associations of IGF-II with disease progression.<br />Results: IGF-II expression was found to be higher in tumors with poor prognosis; this included tumors with advanced stage, poor differentiation, serous histology, and large residual lesions. Patients with high IGF-II had elevated risk for disease progression and death, although the significance became less evident when the analysis was adjusted for clinical and pathologic variables. IGFBP-3 expression was higher in less aggressive tumors, but was not associated with disease progression. The expression of estrogen receptor-alpha had no effect on survival.<br />Conclusion: This study found evidence that IGF-II expression is associated with disease progression, suggesting that IGF-II and IGF signaling are potential targets for ovarian cancer treatment. The study also indicates that IGF-II and IGFBP-3 have limited value in prognosis because of their strong associations with disease stage and tumor grade.
- Subjects :
- Adult
Aged
Aged, 80 and over
Disease Progression
Epithelial Cells metabolism
Epithelial Cells pathology
Estrogen Receptor alpha genetics
Female
Humans
Insulin-Like Growth Factor Binding Protein 3 genetics
Insulin-Like Growth Factor II genetics
Middle Aged
Neoplasm Staging
Ovarian Neoplasms genetics
RNA, Neoplasm genetics
RNA, Neoplasm metabolism
Reverse Transcriptase Polymerase Chain Reaction
Survival Analysis
Biomarkers, Tumor genetics
Gene Expression Regulation, Neoplastic
Ovarian Neoplasms pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1078-0432
- Volume :
- 12
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Clinical cancer research : an official journal of the American Association for Cancer Research
- Publication Type :
- Academic Journal
- Accession number :
- 16489075
- Full Text :
- https://doi.org/10.1158/1078-0432.CCR-05-1801