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Lhermitte-Duclos disease: 11C-methionine positron emission tomography data in 4 patients.
- Source :
-
Surgical neurology [Surg Neurol] 2006 Mar; Vol. 65 (3), pp. 293-6; discussion 296-7. - Publication Year :
- 2006
-
Abstract
- Background: Lhermitte-Duclos disease is a cerebellar lesion, characterized by an overgrowth of cerebellar ganglion cells, which replace granular cells and Purkinje cells. Lhermitte-Duclos disease may be a manifestation of Cowden syndrome (multiple hamartoma-neoplasia syndrome). The nature of LDD, whether neoplastic, dysplastic, or hamartomatous, is still not exactly understood. Metabolic imaging of the amino acid metabolism using PET could be useful for noninvasive characterization of these lesions.<br />Methods: To define the Meth-PET imaging characteristics of these lesions, we undertook a Meth-PET study in 4 patients with LDD after obtaining informed consent. All 4 patients had clinical signs of Cowden syndrome. In 2, the diagnosis was made with MRI; in 2, it was confirmed histologically.<br />Results: Using Meth-PET, the cerebellar lesions had a high methionine uptake, except in the subtotally resected lesion. The uptake of the lesions was markedly higher than that of the contralateral normal regions. The mean L/C ratio was 2.07.<br />Conclusion: 11C-methionine positron emission tomography visualizes the lesion of Lhermitte-Duclos disease as a high uptake area. This amino acid hypermetabolism may be related to the slow growth of the lesions, and is an argument to suggest that patients with LDD should be followed up carefully to detect progression of the cerebellar lesion.
- Subjects :
- Adult
Amino Acids metabolism
Cerebellar Diseases pathology
Cerebellar Diseases surgery
Cerebellar Neoplasms pathology
Cerebellar Neoplasms surgery
Cerebellum diagnostic imaging
Cerebellum pathology
Cerebellum surgery
Dominance, Cerebral physiology
Female
Granular Cell Tumor pathology
Granular Cell Tumor surgery
Hamartoma Syndrome, Multiple pathology
Hamartoma Syndrome, Multiple surgery
Humans
Hyperplasia
Magnetic Resonance Imaging
Male
Purkinje Cells pathology
Syndrome
Carbon Radioisotopes
Cerebellar Diseases diagnostic imaging
Cerebellar Neoplasms diagnostic imaging
Granular Cell Tumor diagnostic imaging
Hamartoma Syndrome, Multiple diagnostic imaging
Methionine analogs & derivatives
Positron-Emission Tomography
Subjects
Details
- Language :
- English
- ISSN :
- 0090-3019
- Volume :
- 65
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Surgical neurology
- Publication Type :
- Academic Journal
- Accession number :
- 16488255
- Full Text :
- https://doi.org/10.1016/j.surneu.2005.06.031