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Fluoxetine alters mu opioid receptor expression in obese Zucker rat extrahypothalamic regions.
- Source :
-
The International journal of neuroscience [Int J Neurosci] 2006 Mar; Vol. 116 (3), pp. 289-98. - Publication Year :
- 2006
-
Abstract
- The aim of this article was to describe the effects of chronic fluoxetine on mu opioid receptor expression in obese Zucker rat extrahypothalamic regions. Male obese Zucker (fa/fa) rats were administered with fluoxetine (10 mg/kg; i.p.) daily for two weeks. Brain regional immunostaining for mu opioid receptor was carried out. An increase in the numbers of neural cells immunostained for mu opioid receptor in caudatus-putamen, dentate gyrus, lateral septum, amygdala, and frontal, parietal, and piriform cortices was observed. Increased mu opioid receptor expression in the central amygdaloid nuclei suggests a decreased opioidergic tone at this level that could be involved in fluoxetine anorectic action.
- Subjects :
- Animals
Brain metabolism
Cell Count
Disease Models, Animal
Immunohistochemistry methods
Male
Rats
Rats, Zucker metabolism
Receptors, Opioid, mu genetics
Brain drug effects
Fluoxetine pharmacology
Gene Expression drug effects
Obesity drug therapy
Receptors, Opioid, mu metabolism
Selective Serotonin Reuptake Inhibitors pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0020-7454
- Volume :
- 116
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- The International journal of neuroscience
- Publication Type :
- Academic Journal
- Accession number :
- 16484055
- Full Text :
- https://doi.org/10.1080/00207450500403231