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Low molecular weight indole fragments as IMPDH inhibitors.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2006 May 01; Vol. 16 (9), pp. 2535-8. Date of Electronic Publication: 2006 Feb 17. - Publication Year :
- 2006
-
Abstract
- The study of non-oxazole containing indole fragments as inhibitors of inosine monophosphate dehydrogenase (IMPDH) is described. The synthesis and in vitro inhibitory values for IMPDH II are discussed.
- Subjects :
- Carbamates chemistry
Carbamates pharmacology
Crystallography, X-Ray
Enzyme Inhibitors chemical synthesis
Enzyme Inhibitors chemistry
Hydrogen Bonding
Indoles chemical synthesis
Indoles chemistry
Models, Molecular
Molecular Structure
Molecular Weight
Oxazoles pharmacology
Phenylurea Compounds chemistry
Phenylurea Compounds pharmacology
Sensitivity and Specificity
Structure-Activity Relationship
Enzyme Inhibitors pharmacology
IMP Dehydrogenase antagonists & inhibitors
Indoles pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0960-894X
- Volume :
- 16
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 16483769
- Full Text :
- https://doi.org/10.1016/j.bmcl.2006.01.089