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Transient elevation of hepatic enzymes in volunteers after intake of alcohol.
- Source :
-
Hepatobiliary & pancreatic diseases international : HBPD INT [Hepatobiliary Pancreat Dis Int] 2006 Feb; Vol. 5 (1), pp. 52-5. - Publication Year :
- 2006
-
Abstract
- Background: In the organs that mediate alcohol effects on the human body and its health, the liver plays a particular important role. This study was designed to detect the changes of hepatic enzymes after alcohol intake and evaluate the corresponding damage to the human body.<br />Methods: Fifteen volunteers were included according to the criteria. After the intake of 80 g ethanol containing beverage, alcohol levels were detected and blood samples were collected at 0.5- to 3-hour interval to detect the levels of hepatic enzymes simultaneously.<br />Results: After the intake of 80 g ethanol, various symptoms occurred in volunteers while the concentration of blood alcohol peaked at 1 hour and normalized within 24 hours. The ratio of alanine aminotransferase (ALT) to aspartate aminotransferase (AST) increased significantly when the venous alcoholic concentration increased from 0 g/L to 1.2 g/L and the levels of alkaline phosphatase (ALP) and gamma-glutamyl transpeptidase (gamma-GT) were elevated when the alcoholic concentration reached 0.4 g/L. No significant changes were noticed in ALT, AST or cholinesterase (CHE).<br />Conclusion: Acute alcohol intoxication may cause the changes of hepatic enzymes and prove the existence of reversible hepatic injury.
- Subjects :
- Adult
Alkaline Phosphatase blood
Biomarkers blood
Central Nervous System Depressants administration & dosage
Dose-Response Relationship, Drug
Ethanol administration & dosage
Female
Humans
Liver drug effects
Male
Middle Aged
Reference Values
gamma-Glutamyltransferase blood
Alanine Transaminase blood
Alcohol Drinking blood
Aspartate Aminotransferases blood
Central Nervous System Depressants pharmacokinetics
Ethanol pharmacokinetics
Liver enzymology
Subjects
Details
- Language :
- English
- ISSN :
- 1499-3872
- Volume :
- 5
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Hepatobiliary & pancreatic diseases international : HBPD INT
- Publication Type :
- Academic Journal
- Accession number :
- 16481283