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Benefits and risks of palliative capecitabine based therapy to elderly patients with advanced colorectal cancer: Danish single centre experiences.
- Source :
-
Acta oncologica (Stockholm, Sweden) [Acta Oncol] 2006; Vol. 45 (1), pp. 67-76. - Publication Year :
- 2006
-
Abstract
- This study aimed to compare efficacy and toxicity of palliative chemotherapy for elderly and younger colorectal cancer patients. Patients aged 24-69 (n = 203) and 70-82 years (n = 57) with advanced colorectal cancer were consequetively treated with first line capecitabine monotherapy or combined with oxaliplatin (XELOX). The response rates were 37% and 33% (P = 0.61), the median times to progression were 5.5 and 6.0 months (P = 0.84, hazard ratio (HR) 1.09; 95% confidence interval: 0.71-1.68), and median overall survival times were 8.4 and 12.5 months (P = 0.07, HR 1.48; 1.04-2.38) for elderly and younger patients, respectively. Elderly patients had similar frequencies of Common Toxicity Criteria (CTC) grade 3 or 4 toxicity (P > 0.05) and number of treatment courses (P = 0.44), and maintained performance status as well as younger patients (P = 0.68). Palliative capecitabine based therapy for advanced colorectal cancer should be considered also for elderly who are in good performance without major comorbidities.
- Subjects :
- Adult
Age Factors
Aged
Aged, 80 and over
Antimetabolites, Antineoplastic adverse effects
Capecitabine
Colorectal Neoplasms mortality
Denmark
Deoxycytidine adverse effects
Deoxycytidine therapeutic use
Disease Progression
Female
Fluorouracil analogs & derivatives
Humans
Male
Middle Aged
Prodrugs adverse effects
Prospective Studies
Risk Assessment
Risk Factors
Survival Analysis
Antimetabolites, Antineoplastic therapeutic use
Colorectal Neoplasms drug therapy
Deoxycytidine analogs & derivatives
Palliative Care
Prodrugs therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 0284-186X
- Volume :
- 45
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Acta oncologica (Stockholm, Sweden)
- Publication Type :
- Academic Journal
- Accession number :
- 16464798
- Full Text :
- https://doi.org/10.1080/02841860500375213