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Apoptosis and melanoma: how new insights are effecting the development of new therapies for melanoma.

Authors :
Hersey P
Source :
Current opinion in oncology [Curr Opin Oncol] 2006 Mar; Vol. 18 (2), pp. 189-96.
Publication Year :
2006

Abstract

Purpose of Review: Melanoma has proven resistant to most available chemotherapy and immunotherapy. Despite a range of different biochemical targets, most agents kill cancer cells by induction of apoptosis.<br />Recent Findings: Investigation of this process has provided insights into the resistance mechanisms in cancer cells and to development of a range of new agents that target apoptosis pathways. These include agents which inhibit antiapoptotic B cell lymphoma-2 family proteins and inhibitor of apoptosis proteins. In addition, a range of signal pathway inhibitors have become available that are able to inhibit signal pathways known to be associated with resistance to apoptosis.<br />Summary: Evaluation of most of these reagents are at a preclinical level but studies on some pathway inhibitors have passed from phase II into phase III studies. Similarly, evaluation of antisense reagents are at an advanced stage. These early trials show much promise and suggest this approach to development of new therapies will lead to much needed advances in treatment of this disease.

Details

Language :
English
ISSN :
1040-8746
Volume :
18
Issue :
2
Database :
MEDLINE
Journal :
Current opinion in oncology
Publication Type :
Academic Journal
Accession number :
16462190
Full Text :
https://doi.org/10.1097/01.cco.0000208794.24228.9f