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Comparison of efficacy of sildenafil-only, sildenafil plus topical EMLA cream, and topical EMLA-cream-only in treatment of premature ejaculation.
- Source :
-
Urology [Urology] 2006 Feb; Vol. 67 (2), pp. 388-91. - Publication Year :
- 2006
-
Abstract
- Objectives: To compare the efficacy of sildenafil (Viagra) only, sildenafil plus topical anesthetic cream (EMLA), and topical EMLA-cream-only to that of placebo in treating premature ejaculation.<br />Methods: A total of 84 patients were enrolled in this study. The duration of premature ejaculation in the patients ranged from 9 to 60 months (mean 32.5 +/- 14.6). Patients were randomized into four groups. Group 1 consisted of 20 patients who took placebo for 2 months. Groups 2 and 3 consisted of 20 and 22 patients, respectively, and they received 50 mg sildenafil 45 minutes before coitus for 2 months. In addition, patients in group 3 applied topical EMLA cream to the glans penis 15 minutes before coitus. The 22 patients in group 4 used topical EMLA-cream-only. After at least eight sexual attempts, the patients' clinical responses were assessed using the patient self-description method. Effectiveness was described as improvement plus cure.<br />Results: The effectiveness was 40% in group 1, 55% in group 2, 86.4% in group 3, and 77.3% in group 4. Of the groups, a significant difference was found in the effectiveness of the treatments (Pearson chi-square= 0.00). No significant difference was found between groups 1 and 2 (P = 0.26). Efficacy was more successful in groups 3 and 4 than in the others (P = 0.00). The difference between groups 3 and 4 was not significant (Pearson chi-square = 0.42).<br />Conclusions: Sildenafil-only was not superior to placebo or combination treatment. Topical EMLA-cream-only had equal effectiveness to that of sildenafil plus topical EMLA treatment. The use of topical EMLA-cream-only seems to be an effective treatment of premature ejaculation.
- Subjects :
- Administration, Topical
Adult
Drug Therapy, Combination
Humans
Lidocaine, Prilocaine Drug Combination
Male
Middle Aged
Ointments
Purines
Sildenafil Citrate
Sulfones
Time Factors
Anesthetics, Local administration & dosage
Ejaculation drug effects
Lidocaine administration & dosage
Phosphodiesterase Inhibitors administration & dosage
Piperazines administration & dosage
Prilocaine administration & dosage
Sexual Dysfunction, Physiological drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1527-9995
- Volume :
- 67
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Urology
- Publication Type :
- Academic Journal
- Accession number :
- 16461091
- Full Text :
- https://doi.org/10.1016/j.urology.2005.09.002