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Sydenham's chorea is associated with decreased verbal fluency.
- Source :
-
Parkinsonism & related disorders [Parkinsonism Relat Disord] 2006 Apr; Vol. 12 (3), pp. 165-7. Date of Electronic Publication: 2006 Feb 03. - Publication Year :
- 2006
-
Abstract
- Background: Sydenham's chorea (SC) is a disorder associated with rheumatic fever and related to Streptococcus-induced immune reaction cross-reactive with basal ganglia antigens. Obsessive-compulsive disorder and other behavioral abnormalities have been described in SC. There are scarce data of cognitive function in this condition.<br />Objective: To assess verbal fluency in patients with SC.<br />Patients and Methods: We have compared the semantic (SVF) and phonemic verbal fluency (PVF) of 20 subjects with SC and 40 controls matched by age, gender and years of school.<br />Results: The scores of the control group on the SVF and PVF tests were 26.3 +/- 5.7 and 18.0 +/- 6.4 whereas the SC patients scored 25.1 +/- 6.9 and 12.5 +/- 8.2. PVF was significantly decreased in the SC group (p < 0.01).<br />Conclusion: SC is associated with reduction of PVF. This finding may reflect disruption of the dorsolateral prefrontal-striatal circuit caused by the auto-immune process characteristic of SC.
Details
- Language :
- English
- ISSN :
- 1353-8020
- Volume :
- 12
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Parkinsonism & related disorders
- Publication Type :
- Academic Journal
- Accession number :
- 16460985
- Full Text :
- https://doi.org/10.1016/j.parkreldis.2005.11.003