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Design and synthesis of 7H-pyrrolo[2,3-d]pyrimidines as focal adhesion kinase inhibitors. Part 1.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2006 Apr 15; Vol. 16 (8), pp. 2173-6. Date of Electronic Publication: 2006 Feb 03. - Publication Year :
- 2006
-
Abstract
- A series of 2-amino-9-aryl-7H-pyrrolo[2,3-d]pyrimidines were designed and synthesized to target focal adhesion kinase (FAK). A number of these pyrrolopyrimides exhibited low micromolar inhibitory activities against focal adhesion kinase, and their preliminary SAR was established via systematic chemical modifications. The 2-amino-9-aryl-7H-pyrrolo[2,3-d]pyrimidines represent a new class of kinase inhibitors.
- Subjects :
- Antineoplastic Agents pharmacology
Cell Line, Tumor
Drug Screening Assays, Antitumor
Enzyme Inhibitors pharmacology
Humans
Pyrimidines chemical synthesis
Pyrimidines pharmacology
Pyrroles chemical synthesis
Pyrroles pharmacology
Structure-Activity Relationship
Antineoplastic Agents chemical synthesis
Enzyme Inhibitors chemical synthesis
Focal Adhesion Protein-Tyrosine Kinases antagonists & inhibitors
Subjects
Details
- Language :
- English
- ISSN :
- 0960-894X
- Volume :
- 16
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 16458503
- Full Text :
- https://doi.org/10.1016/j.bmcl.2006.01.053